Fernando Carlos Giacomelli

Centro de Ciências Naturais e Humanas, Universidade Federal do ABC, Santo André, Brazil

Tailoring Polymer Colloids through Supramolecular Interactions: Polymersomes, Polyplexes and Polymer-Metal Hybrids towards a Toolbox for Nanofactories and Nanotherapeutics

Fernando Carlos Giacomelli

Biography

Fernando Carlos Giacomelli is an Associate Professor (2010 – Current) at the Federal University of ABC (UFABC) located in São Paulo state (Brazil). He graduated in Chemistry from the Federal University of Santa Catarina – UFSC (Florianópolis, Brazil) and he earned his PhD in Physical Chemistry in 2009 from the Federal University of Rio Grande do Sul – UFRGS (Porto Alegre, Brazil) with experimental activities partially conducted in the Institute of Macromolecular Chemistry – Czech Academy of Sciences (Prague, Czech Republic). He was a SAXS Beamline Scientist (2009 – 2010) affiliated to the Brazilian Synchrotron Light Laboratory – LNLS (Campinas, São Paulo) and a Visiting Researcher (2019 – 2020) in the Parisian Institute of Molecular Chemistry (IPCM) at the Sorbonne University (Paris, France). He was the Coordinator (2016 – 2018) of the Biotechnology Graduate Program (MSc & PhD Degrees) and he is currently the Coordinator of the Nanomedicine Research Unit (NanoMed) at UFABC. He is an Associate Editor of the Journal of the Brazilian Chemical Society since 2018. He is currently awarded with a CNPq-1D Productivity Research Fellow. Prof. Fernando is currently involved with different international research projects including a FAPESP Themed project, a FAPESP-CNRS joint project, INCT Polissacarídeos, European H2020 Marie Skłodowska-Curie Actions, and projects in collaboration with industries such as Indorama Ventures. His research interests are focused on the self-assembly of block copolymers and biomacromolecules, and by combining microscopic, spectroscopy and scattering tools, the research group investigates how these constructs behave in contact with living systems in an approach involving inputs from synthetic chemistry, soft matter physics and biology.

Abstract

Polymer colloids are complex materials with versatile structures and morphologies that have the potential to be used in a wide array of fields. In this regard, structural changes of polymeric assemblies can be induced by disparate environmental conditions found in biosystems and therefore, such responsive platforms with tunable properties are attractive for applications in life sciences. Accordingly, this speech aims to disseminate the recent findings of the research group in this framework, particularly focusing on three different subjects: i) investigations concerning the permeability of polymersomes towards the manufacturing of nanofactories for biotransformations,[1,2] ii) manufacturing of environmentally-responsive supramolecular assemblies for the delivery of molecular and macromolecular therapeutics[3-5] and iii) the formation of biomacromolecular coronas when nanomaterials are swimming in protein environments.[6,7]

References

  1. Du, H. et al. Engineering of ion permeable planar membranes and polymersomes based on β-cyclodextrin-cored star copolymers, Journal of Colloid and Interface Science, 630, 465-476, 2023.
  2. de Oliveira, F.A. et al. Role of Membrane Features on the Permeability Behavior of Polymersomes and the Potential Impacts on Drug Encapsulation and Release, Biomacromolecules, 24 (5), 2291-2300, 2023.
  3. de Oliveira, F.A. et al. Balancing gene transfection and cytotoxicity of nucleic acid carriers with focus on ocular and hepatic disorders: evaluation of hydrophobic and hydrophilic polyethyleneimine derivatives, Journal of Materials Chemistry B, 11, 4556-4571. 2023.
  4. Albuquerque, L. J. C. et al. Nucleic acid delivery to retinal cells using lipopeptides as a potential tool towards ocular gene therapies. Journal of Colloid and Interface Science, 655, 346-356, 2024.
  5. Albuquerque, L. J. C. et al. pH-responsive polymersome-mediated delivery of doxorubicin into tumor sites enhances the therapeutic efficacy and reduces cardiotoxic effects. Journal of Controlled Release, 332, 529-538, 2021.
  6. Du, H. et al. Polyglycidol-Stabilized Nanoparticles as a Promising Alternative to Nanoparticle PEGylation: Polymer Synthesis and Protein Fouling Considerations. Langmuir, 36, 1266-1278, 2020.
  7. Giacomeli F. C. et al. Light scattering evidence of selective protein fouling on biocompatible block copolymer micelles. Nanoscale, 4, 4504-4514, 2012.
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