University Grenoble Alpes, CNRS, CERMAV, Grenoble, France
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Issei Otsuka is a CNRS researcher at Grenoble Alpes University, CNRS, CERMAV. He was born and educated in Japan where he earned his PhD degree from Hokkaido University in 2008. After PhD, he was awarded a post-doc fellowship of the Japan Society for the Promotion Science and moved to France. He became the CNRS permanent researcher in 2010. He obtained his Research Habilitation Degree (HDR) from Grenoble Alpes University in 2019. He was a visiting professor at McGill University in Canada (2018.03-2018.08) and a visiting scientist at The University of Montreal in Canada (2017.03-2018.02), and The University of Texas at Austin in USA (2011.03-2011.06). His research activity focusses on physical chemistry of macromolecules derived from sustainable “green” resource, such as poly-/oligosaccharides, towards nano-/bio-material applications. Since he joined the CNRS, he has worked on one of the main research topics in the self-assembly of glycopolymers group at CERMAV, i.e. self-assembly of carbohydrate-based block copolymers in solution (nanoparticles) and solid state (nano-organized thin films). Recently, he has been developing within his team an original theme of structuring functional polysaccharide derivatives by electrospinning toward biomedical applications including chiral resolution membranes and photo-responsive textiles. He is coordinating several international collaborative research projects with Canada, Germany, Spain, Russia, Japan, Taiwan, India etc. and national research projects granted by French National Research Agency (ANR).
There has recently been a sudden rise in demand for nonwoven textiles that are a key component of disposable face masks due to epidemic infectious diseases. This has focused more and more attention to electrospinning, a well-established method of nanofibrous textile fabrication. Indeed, electrospun textiles show superior mechanical resistance, i.e., high tensile strength and Young’s modulus, when their fiber diameters and alignments are optimized simply by adjusting technical electrospinning parameters. Besides, the high specific surface area of electrospun nanofibrous textiles arising from the nanoscale interstitial spaces between the fibers makes them a promising scaffold to filter biological and chemical contaminants. Currently, raw materials of electrospun textiles include bio-based polymers and are not limited to fossil-based polymers. Electrospun textiles made of polysaccharides and their derivatives are one of the most rapidly-growing product markets for various biomedical applications. In this context, we are developing new types of functional polysaccharide-based textiles via electrospinning, aimed at diverse biomedical applications including membrane filters for efficient resolutions of biologically essential chiral molecules,[1,2] as well as photo-responsive textiles.[3,4] In this talk, for the former topic, a new approach for effective chiral resolution via filtration process using electrospun membranes made from polysaccharidic chiral selectors that have been used as packing materials of chiral HPLC columns will be introduced. For the latter topic, light-driven wettability changes and asymmetric deformations of electrospun self-standing textiles consisting of a reversible molecular
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