IMP, CNRS, INSA-lyon, Lyon, France
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Julien Bernard completed his PhD in Bordeaux in 2003 (LCPO) and joined CAMD (UNSW, Australia) as post-doctoral fellow between 2004 and 2005 under the supervision of Pr M Stenzel , C Barner-Kowollik and T. P Davis. After one year in the group of Pr B. Charleux (Université Paris 6, he was hired by CNRS at INSA-Lyon (IMP). His research activities are mainly directed towards macromolecular engineering, and (nano)materials science. Over the two last decades, he has developed a strong expertise in block copolymer self-assembly (in solution and in bulk), production of colloids (nanocapsules, nanoparticles) using various techniques such as nanoprecipitation, interfacial polymerization in mini-emulsion conditions or conventional RAFT PISA, engineering of (nanostructured) polymer networks and step growth polymerizations. He has published 85 papers and 7 patents.
Fluorescent Organic Nanoparticles (FONs) with emission wavelengths in far-red/near infrared (NIR) domain are an emerging class of nanomaterials with great potential in bioimaging, biosensing and therapy. FONs combine the brightness and the photo-stability of the inorganic nanoparticles such as quantum dots and outperform both soluble dyes and their existing inorganic counterparts in terms of biocompatibility without interfering with normal biochemical processes. Recently, we reported the preparation of amorphous FONs stabilized by a polymer corona by nanoprecipitation of Aggregation-Induced Emission (AIE) fluorophores (Fig 1).1 We showed that crystallization of these amorphous precursors affords the design of nanoscale biotracers with high brightness suitable for in vivo imaging. Indeed the transition from the amorphous state to the crystalline state (triggered by sonication or freeze drying) leads to a dramatic restriction of intramolecular motion and a great enhancement in optical properties (fluorescence quantum yield and brightness).
Xibo Yan, Maxime Remond, Zheng Zheng, Elsa Hoibian, Christophe Soulage, Stéphane Chambert, Chantal Andraud, Boudewijn Van der Sanden, Francois Ganachaud, Yann Bretonnière, Julien Bernard ACS Applied Materials Interfaces 2018, 10, 25154–25165. General and Scalable Approach to Bright, Stable and Functional AIE Fluorogen Colloidal Nanocrystals for in Vivo Imaging
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