Biography

Regina Célia M. de Paula is a full professor at the Federal University of Ceará and currently holds the position of Pro-Rector of Research and Postgraduate Studies. His training includes a degree in Industrial Chemistry from the Federal University of Pernambuco (1985), a master’s degree in Inorganic Chemistry from the Federal University of Ceará (1990) and a PhD in Polymer Chemistry from the University of Manchester (1995). Throughout her academic career, she has played several leadership roles, including Director of the UFC Science Center (2019-2023), Coordinator of Academic Programs at the Science Center (2015-2019), Coordination of the Graduate Program in Chemistry (2013-2015) and Head of the Department of Organic and Inorganic Chemistry at the Federal University of Ceará (2009 to 2012). Participates in important networks and research projects, such as the National Institutes of Science and Technology in Complex Materials and Polysaccharides, as well as in the PRINT project of UFC. Her work focuses on the characterization and modification of polysaccharides,
as well as the use of nano and microparticles of biopolymers for the controlled release of drugs. She has contributed 128 scientific articles, 4 book chapters and 1 book, in addition to having a registered patent. As a supervisor, she supervised and co-supervised more than 70 students, including post-doctoral students, doctoral students, master students and scientific initiation interns.

Abstract

Cancer is still one of the leading causes of global mortality, registering around 10 million deaths in 2020 [1]. Approaches to combating this disease include prevention, advanced diagnostics and innovative therapies. In addition to conventional modalities such as surgery, radiotherapy and chemotherapy, photodynamic therapy (PDT) has stood out for its combinatorial potential with chemotherapy. PDT uses light to trigger damage or death of cancer cells, often through the generation of reactive oxygen species (ROS). However, traditional phototherapeutic agents face significant limitations, such as low water solubility and limited accumulation efficiency in target tumours [3]. In this context, polysaccharide-based drug delivery nanosystems have emerged as a promising strategy to overcome these limitations. Our research group has been working on the development of delivery systems dually loaded with anticancer and PDT agents, with the aim of minimising toxicity in healthy tissues and enhancing efficacy against tumour cells. Through these nanoplatforms, we aim not only to improve therapeutic efficacy, but also to increase treatment specificity, thus contributing to significant advances in cancer treatment.

References

[1] Ferlay J et al. Global Cancer Observatory: Cancer Today. Lyon: International Agency for Research on Cancer; 2020 (https://gco.iarc.fr/today, accessed February 2021).
[2] Makvandi, P. et al Carbohydr. Polym. 2020,250, 116952.
[3] (Xu et al, Carbohydr. Polym. 2023, 301, 120311.