University of Rennes, CNRS, ISCR, Rennes, France
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Sophie Guillaume is a CNRS research Professor at Rennes University (CNRS-ISCR). She is presently deputy director of the Rennes Institute of Chemical Science (ISCR-Rennes), France. She has been elected National Representative for France at IUPAC – Polymer Division (2022-), and president of the French Polymer Group (GFP, 2018-2021). She is currently Associate Editor at ACS Applied Polymer Materials and member of the Advisory Board at RSC Polymer Chemistry and Wiley Journal of Applied Polymer Science.
Sophie Guillaume received her PhD degree from the University of Syracuse, New York, USA, and then joined the Alternative Energies and Atomic Energy Commission (CEA), France, for her postdoctoral research. Shen then joined the National Center for Scientific Research (CNRS), and next moved to the Laboratoire de Chimie des Polymères Organiques (LCPO, Bordeaux, France), and last to ISCR in Rennes, France. She has +130 publications, 1 book, 4 book chapters, 25 press releases, and 33 patents.
Prof S. Guillaume’s current research, developed in collaboration with industrial partners (TotalEnergies, Bostik, Arkema, Demeta) and within academic projects, involves green and bio-based approaches towards the preparation of original functional and reactive polymers, including polyesters, polycarbonates, polyurethanes, and polyolefins for the development of new polymer materials, emphasizing on polymerization catalysis and structure-properties relationships.
Poly(hydroxyalkanoate)s (PHAs) are a class of natural or synthetic aliphatic polyesters which feature the same three-carbon backbone structure, differing by their substituent (R) along their backbone. PHAs are attracting considerable interest as circular engineering plastics. These biobased, biocompatible, degradable and recyclable polymers represent a targeted choice for in particular single-use plastics, packaging, and biomedical applications.
Recent highlights of our research in the field of 1) tunable catalytic systems for the ring-opening (co)polymerization (ROP) of functional 4-subtituted b-propiolactones BPLFG (FG = alkyl, alkoxy-methylene, alkoxycarbonyl), into their corresponding PHAs, 2) original sequence controlled PHAs, featuring a high degree of control over molecular and microstructural characteristics, and 3) PHA copolymers as promising drug delivery systems, will be presented.
Our most significant achievements in this endeavor include the development of strategies enabling the synthesis of stereoregular and alternated PHA (co) polymers, and evidences the close relationship between the catalytic system, the chemical structure, the composition and topology of the macromolecules. The combination of the stereoelectronic environment and non-covalent interactions within the catalyst/active species, and of the lactone substituent in b-position is a key parameter for the control of the PHA stereochemistry.
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